We are grateful to David Cane, Scott Virgil, Robert M. Coates, and David Christianson for their pioneering studies, invaluable advice, encouragement, and materials. We thank Indira Wu, Chris Farwell, and Jack Zhang for assistance. R.L. acknowledges the support of NIH fellowship F32GM095061. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. K.S.R. thanks the Deutscher Akademischer Austauschdienst (DAAD) for a postdoctoral fellowship. K.Z.K. and R.Z.K. acknowledge the support of Summer Undergraduate Research Fellowships from the California Institute of Technology. T.H. was funded by the FWF grant number: J3327-B21.
High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase†
Article first published online: 26 MAR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 21, pages 5571–5574, May 17, 2013
How to Cite
Lauchli, R., Rabe, K. S., Kalbarczyk, K. Z., Tata, A., Heel, T., Kitto, R. Z. and Arnold, F. H. (2013), High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase . Angew. Chem. Int. Ed., 52: 5571–5574. doi: 10.1002/anie.201301362
- Issue published online: 10 MAY 2013
- Article first published online: 26 MAR 2013
- Manuscript Received: 15 FEB 2013
- NIH. Grant Number: F32GM095061
- Deutscher Akademischer Austauschdienst (DAAD)
- FWF. Grant Number: J3327-B21
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