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Gold Catalysis: Highly Functionalized Cyclopentadienes Prepared by Intermolecular Cyclization of Ynamides and Propargylic Carboxylates

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  • We thank Umicore AG & Co. KG for the generous donation of gold salts.

Abstract

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When an ynamide meets a gold carbenoid: Highly electrophilic gold carbenoids available from propargylic esters by means of 1,2-acyloxy migration open up new reaction pathways for ynamide gold chemistry. In this way highly functionalized cyclopentadiene derivatives become accessible (see scheme; EWG=electron-withdrawing group).

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