These authors contributed equally to this work.
A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells†
Article first published online: 23 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 28, pages 7266–7271, July 8, 2013
How to Cite
Lin, L., Tian, X., Hong, S., Dai, P., You, Q., Wang, R., Feng, L., Xie, C., Tian, Z.-Q. and Chen, X. (2013), A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells. Angew. Chem. Int. Ed., 52: 7266–7271. doi: 10.1002/anie.201301387
This work was supported by the National Instrumentation Program under grant number2011YQ030124 (grant to Z.T. and X.C.), the National Basic Research Program of China (973 Program) under grant number 2012CB917303 (grant to X.C.), and the National Natural Science Foundation of China under grant number 21172013 (grant to X.C.). We thank Prof. C. Yan, Prof. Y. Li, and Prof. Y. Huang for sharing the instruments. SERS=surface-enhanced Raman spectroscopy.
- Issue published online: 4 JUL 2013
- Article first published online: 23 MAY 2013
- Manuscript Revised: 22 APR 2013
- Manuscript Received: 17 FEB 2013
- National Instrumentation Program. Grant Number: 2011YQ030124
- National Basic Research Program of China (973 Program). Grant Number: 2012CB917303
- National Natural Science Foundation of China. Grant Number: 21172013
- Raman spectroscopy;
- surface science
Direct detection of glycans on live cells using surface-enhanced Raman scattering (SERS) has been shown. A bioorthogonal Raman reporter was directly installed onto the monosaccharide analogs. Once metabolically incorporated into cell surface glycans, the Raman reporter was detected using SERS (see picture).