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Keywords:

  • bioorthogonality;
  • cells;
  • glycans;
  • Raman spectroscopy;
  • surface science
Thumbnail image of graphical abstract

Direct detection of glycans on live cells using surface-enhanced Raman scattering (SERS) has been shown. A bioorthogonal Raman reporter was directly installed onto the monosaccharide analogs. Once metabolically incorporated into cell surface glycans, the Raman reporter was detected using SERS (see picture).