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Keywords:

  • antitumor agents;
  • β-cyclodextrin;
  • biodistribution;
  • paclitaxel;
  • polyrotaxanes
Thumbnail image of graphical abstract

Cap it all: A β-cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and β-cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug-conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs the life of tumor-bearing mice better than Taxol.