This work was supported by the Natural Science Foundation of China (Nos. 51033002 and 51273090).
Synthesis of Paclitaxel-Conjugated β-Cyclodextrin Polyrotaxane and Its Antitumor Activity†
Article first published online: 5 JUN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 28, pages 7272–7277, July 8, 2013
How to Cite
Yu, S., Zhang, Y., Wang, X., Zhen, X., Zhang, Z., Wu, W. and Jiang, X. (2013), Synthesis of Paclitaxel-Conjugated β-Cyclodextrin Polyrotaxane and Its Antitumor Activity. Angew. Chem. Int. Ed., 52: 7272–7277. doi: 10.1002/anie.201301397
- Issue published online: 4 JUL 2013
- Article first published online: 5 JUN 2013
- Manuscript Revised: 14 APR 2013
- Manuscript Received: 17 FEB 2013
- Natural Science Foundation of China. Grant Numbers: 51033002, 51273090
- antitumor agents;
Cap it all: A β-cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and β-cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug-conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs the life of tumor-bearing mice better than Taxol.