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Formation of C[BOND]SCF3 Bonds through Direct Trifluoromethylthiolation

Authors

  • Dr. Anis Tlili,

    1. Leibniz-Institut für Katalyse, Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany)
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  • Dr. Thierry Billard

    Corresponding author
    1. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS-UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon (France)
    2. CERMEP-In vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon (France)
    • Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS-UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon (France)

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  • T.B. thanks the CNRS and the réseau français du fluor, A.T. the Leibniz-Institut für Katalyse and Prof. Matthias Beller (LIKAT) for support.

Abstract

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Modern chemistry with an old substituent: The introduction of the SCF3 group into organic substrates is a challenging task because of harsh or specific synthetic methods. However, recent advances in the formation of C[BOND]SCF3 bonds include the trifluoromethylthiolation with transition-metal-free systems or in the presence of palladium, nickel, or copper catalysts (see scheme).

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