Precise selectivity control in transition-metal catalysis is critical for modern chemical synthesis. In their Communication on page 3878 ff., J. N. H. Reek and P. Dydio demonstrate that substrate preorganization through noncovalent supramolecular interactions with the ligand is a powerful enabling strategy to control selectivity, and gives access to usually unfavored products. As exemplified for the Rh-catalyzed hydroformylation of vinyl arenes, this approach opens up new avenues in the synthesis of valuable compounds.
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