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A Magnesium-Mediated Cascade Assembly for the Atom-Economical Synthesis of Bis(imidazolidine-2,4-dione)s


  • We thank the EPSRC (UK) for funding.


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Bicycle race: Structurally complex bis(imidazolidine-2,4-dione) molecules may be synthesized with complete atom-efficiency from simple building blocks by a kinetically controlled magnesium-mediated cascade of intermolecular isocyanate insertion and intramolecular alkyne hydroamination reaction steps.

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