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Keywords:

  • Alzheimer’s disease;
  • amyloid β-peptides;
  • high-pressure chemistry;
  • NMR spectroscopy
Thumbnail image of graphical abstract

Folding under pressure: High-pressure NMR spectroscopy detects three different conformational states of the Aβ-peptide in solution: a compactly folded state 1, a partially folded state 2′, and a random-coil like state 2′′ (see plot, p=population). At ambient pressure the folded state 1 dominates which probably has a high affinity to fibrils and thus may promote fibril formation.