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Optimizing P,N-Bidentate Ligands for Oxidative Gold Catalysis: Efficient Intermolecular Trapping of α-Oxo Gold Carbenes by Carboxylic Acids


  • We thank the NIGMS (R01 GM084254) for generous financial support.


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Control confirmed: Optimization of P,N-bidentate ligands (L) reveals the importance of conformation control for intermolecular trapping of reactive α-oxo gold carbene intermediates. As a result, the highly efficient and broadly applicable synthesis of carboxymethyl ketones from readily available carboxylic acids and terminal alkynes proceeds under mild reaction conditions.