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Keywords:

  • carbohydrates;
  • enzymes;
  • glycopeptides;
  • protein folding;
  • synthesis design
Thumbnail image of graphical abstract

From the stacks: A novel method for construction of a high-mannose-type glycan library by systematic enzymatic trimming of a single synthetic Man9-based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M8-9 and G1M8-9 derivatives was demonstrated. G=glucose, M=mannose.