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Keywords:

  • Brønsted acid;
  • electrocyclic reactions;
  • heterocycles;
  • reaction mechanisms;
  • synthetic methods
Thumbnail image of graphical abstract

Electric slide: Described is a general, operationally simple, highly enantioselective Brønsted acid catalyzed condensation/6π-electrocyclization reaction between hydrazones and α,β-unsaturated aldehydes that yields valuable 1,4-dihydropyridazines. The reaction exhibits high tolerance towards functional groups and affords products with up to 98 % ee.