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Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide


  • This work was supported by the NRF of S. Korea: Pioneer (2011-0001800, H.L.), Future-based Technology Development Programs (2009-0092222, H.L.), National Junior Research Fellowship (2012H1A8002613, S.H.), and the Institute for Basic Science (IBS) (W.J.K.). This work is also supported by the Ministry of Health & Welfare (A120170, H.L.).


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Capture and release: The material-independent surface chemistry of a poly(norepinephrine) (pNE) which exhibits perfect smoothness at the nanometer scale is controlled by 3,4-dihydroxybenzaldehyde-norepinephrine (DHBA-NE) conjugates. The pNE layer containing DHBA-NE serves to store and release small therapeutics such as nitric oxide.