Ruthenium-Catalyzed Carbonylative C[BOND]C Coupling in Water by Directed C[BOND]H Bond Activation


  • We thank the state of Mecklenburg-Vorpommern and the Bundesministerium für Bildung und Forschung (BMBF) for financial support. We also thank Dr. W. Baumann, Dr. C. Fischer, and S. Buchholz (LIKAT) for analytical support.


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First things first: The title reaction of arenes bearing ortho-directing groups (DG) in the presence of a ruthenium catalyst and aryl iodide is presented. The reaction is general for variously substituted aryl iodides to give ketones in moderate to good yields, and water serves as the solvent. The system is highly selective towards the mono-carbonylative arylation by ortho C[BOND]H functionalization. cod=cyclo-1,5-octadiene.