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Keywords:

  • antitumor agents;
  • cysteine;
  • peptides;
  • protecting groups;
  • thiocoraline
Thumbnail image of graphical abstract

Another (orthogonal) dimension: The solid-phase synthesis of thiocoraline was accomplished for the first time by a combined approach involving chemical and enzymatic methods. One-pot cleavage of the phenylacetamidomethyl protecting group using immobilized penicillin G acylase enzyme (see picture) and disulfide formation are the key steps of the synthetic strategy.