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The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns

Authors

  • Dr. André Nadler,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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    • These authors contributed equally to this work.

  • Dr. Gregor Reither,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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    • These authors contributed equally to this work.

  • Suihan Feng,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Frank Stein,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Dr. Sabine Reither,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Dr. Rainer Müller,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Priv.-Doz. Dr. Carsten Schultz

    Corresponding author
    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
    • Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)

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  • We thank the Advanced Light Microscopy Facility (ALMF) of EMBL for expert support in microscopy. We acknowledge financial support by the DFG (Transregio 83).

Abstract

original image

Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca2+]i) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.

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