A Supramolecular Peptide Synthesizer

Authors


  • We thank the DFG (SFB 765 and SPP 1623), the Fonds der Chemischen Industrie, and the Boehringer-Ingelheim foundation (Plus 3 award) for support.

Abstract

original image

Line up for synthesis! In a recent report the Leigh group described a rotaxane-based setup for the sequence-specific synthesis of small peptides, which runs automatically once started. This molecular machine combines elements from both chemical and biochemical peptide (bio-)syntheses, which are discussed in this Highlight.

Ancillary