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Keywords:

  • peptide synthesis;
  • peptides;
  • polypeptide biosynthesis;
  • ribosomes;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Line up for synthesis! In a recent report the Leigh group described a rotaxane-based setup for the sequence-specific synthesis of small peptides, which runs automatically once started. This molecular machine combines elements from both chemical and biochemical peptide (bio-)syntheses, which are discussed in this Highlight.