This work was supported financially by the NSFC (No. 21002068, 21172170, and 21225208). We also thank Dr. Dominique Cahard (CNRS & Université et INSA de Rouen, France) for his helpful discussions and suggestions.
Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles†
Article first published online: 24 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 24, pages 6255–6258, June 10, 2013
How to Cite
Li, F., Nie, J., Sun, L., Zheng, Y. and Ma, J.-A. (2013), Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles. Angew. Chem. Int. Ed., 52: 6255–6258. doi: 10.1002/anie.201301870
- Issue published online: 5 JUN 2013
- Article first published online: 24 APR 2013
- Manuscript Received: 5 MAR 2013
- NSFC. Grant Numbers: 21002068, 21172170, 21225208
Silver screen: The title reaction provides a convenient and efficient method for the construction of 5-substituted 3-trifluoromethylpyrazoles under mild reaction conditions. By using this protocol, the marketed drug Celecoxib (antiarthritic) could be easily synthesized (see scheme; DMF=N,N-dimethylformamide).