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Keywords:

  • alkynes;
  • cycloaddition;
  • fluorine;
  • regioselectivity;
  • silver
Thumbnail image of graphical abstract

Silver screen: The title reaction provides a convenient and efficient method for the construction of 5-substituted 3-trifluoromethylpyrazoles under mild reaction conditions. By using this protocol, the marketed drug Celecoxib (antiarthritic) could be easily synthesized (see scheme; DMF=N,N-dimethylformamide).