Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery


  • This work was funded by NIH 1R01NS064404 and NSF DMR1206426. LRV was supported by the Amgen Scholars Program at UW. TEM studies were conducted at the Fred Hutchinson Cancer Research Center’s Electron Microscopy Services Core.


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A small case of love and hate: A block-statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value- and reduction-responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.