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A Brief History of G-Protein Coupled Receptors (Nobel Lecture)

Authors

  • Prof. Robert J. Lefkowitz

    Corresponding author
    1. Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710 (USA)
    • Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710 (USA)

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  • Copyright© The Nobel Foundation 2012. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.

Abstract

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The idea of receptors has fascinated scientists for more than a century. Today it is known that the G-protein coupled receptors (GPCRs) represent by far the largest, most versatile and most ubiquitous of the several families of plasma membrane receptors. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs.

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