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Near-Infrared- and pH-Responsive System for Reversible Cell Adhesion using Graphene/Gold Nanorods Functionalized with i-Motif DNA

Authors

  • Wen Li,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Jiasi Wang,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Prof. Jinsong Ren,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • Prof. Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
    • Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022 (China)
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  • This work was supported by 973 Project (2011CB936004, 2012CB720602), and NSFC (21210002, 91213302, 21072182).

Abstract

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It′s a keeper! A dual near-infrared (NIR)- and pH-responsive system for the controlled catch-and-release of cells was achieved using graphene/Au nanorods as a substrate and double-stranded DNA as a switchable linker for cell immobilization (see scheme). This substrate was shown to respond to cycles of NIR light and changes in pH, and released undamaged cells from the surface.

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