A Convergent Total Synthesis of 19-Hydroxysarmentogenin


  • This research was financially supported by the Funding Program for Next Generation World-Leading Researchers (JSPS) to M.I. and a Grant-in-Aid for Young Scientists (B) (JSPS) to D.U. A fellowship from JSPS to S.K. is gratefully acknowledged. We thank Dr. Kenji Yoza (Bruker AXS) for X-ray crystallographic analyses.


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19 in 19: A convergent total synthesis of 19-hydroxysarmentogenin has been achieved, starting from three simple fragments. The desired product was synthesized in 19 steps from the AB ring system with the installation of six stereocenters and the formation of three C[BOND]C bonds.