Enantiopure Water-Soluble [Fe4L6] Cages: Host–Guest Chemistry and Catalytic Activity


  • This work was supported by the Swiss National Science Foundation (SNSF) and the European Research Council. We thank the EPSRC Mass Spectrometry Service at Swansea for conducting FT-ICR MS experiments.


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Inside information: The new enantiopure cage molecule ΔΔΔΔ-Fe4L6 (and its enantiomer, ΛΛΛΛ-Fe4L6) was prepared by subcomponent self-assembly. It binds a range of organic guests (A, see scheme) in its cavity and distinguishes between the enantiomers of a chiral organic guest. Host ΔΔΔΔ-Fe4L6 is also a catalyst for the hydrolysis (giving B and C) of the neurotoxic organophosphate dichlorvos.