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Driving Force for Oxygen-Atom Transfer by Heme-Thiolate Enzymes


  • Support of this research by the National Institutes of Health (2R37 GM036298), the European Social Fund (080935557), and the European Union integrated project, Peroxicats (265397), are gratefully acknowledged.


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Absolutely: Redox potentials for three redox couples in AaeAPO-catalyzed reactions have been measured, thus placing these heme-thiolate reactive intermediates on an absolute energy scale for the first time. The importance of the axial thiolate ligand and the basic nature of compound II ferryl oxygen atom are discussed in terms of these redox potentials.