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Thermostable Branched DNA Nanostructures as Modular Primers for Polymerase Chain Reaction

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  • We acknowledge support from USDA NE-SARE, USDA AFRI, Bill & Melinda Gates Foundation, and NY Center for Advanced Materials Processing.

Abstract

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Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

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