We gratefully acknowledge support from theSpanish Government (CTQ2009-13699, CTQ2012-32621, RiRAAF RETICS RD12/0013/0009, Ramon y Cajal contract RyC2007-00476 to V.L.-V. and JAE-Predoc 2011-00740 to V.V.-C.).
Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse†
Article first published online: 9 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 25, pages 6476–6479, June 17, 2013
How to Cite
Vendrell-Criado, V., Rodríguez-Muñiz, G. M., Cuquerella, M. C., Lhiaubet-Vallet, V. and Miranda, M. A. (2013), Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse. Angew. Chem. Int. Ed., 52: 6476–6479. doi: 10.1002/anie.201302176
- Issue published online: 11 JUN 2013
- Article first published online: 9 MAY 2013
- Manuscript Received: 14 MAR 2013
- Spanish Government. Grant Numbers: CTQ2009-13699, CTQ2012-32621, RiRAAF RETICS RD12/0013/0009, RyC2007-00476
- cyclobutane pyrimidine dimers;
- DNA damage;
- triplet excited states
A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage.