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Keywords:

  • cyclobutane pyrimidine dimers;
  • DNA damage;
  • photochemistry;
  • pyrimidones;
  • triplet excited states
Thumbnail image of graphical abstract

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage.