Multimodal Magnetic Core–Shell Nanoparticles for Effective Stem-Cell Differentiation and Imaging

Authors


  • This work was financially supported by the NIH Director’s Innovator Award [(1DP20D006462-01), K.B.L.] and a N.J. Commission on Spinal Cord grant [(09-3085-SCR-E-0), K.B.L.]. P.T.Y. would like to acknowledge NIH Biotechnology Training Grant for support. We would like to thank Prasad Subramaniam and Nicholas Pasquale for their useful comments on the manuscript.

Abstract

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Special delivery! The title system, composed of a highly magnetic core surrounded by a thin uniform gold shell, has been synthesized and applied to the magnetically facilitated delivery of genetic material (siRNA or plasmid DNA) into neural stem cells (NSCs) for controlling their neural differentiation in a spatiotemporally controlled, biocompatible manner.

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