Design and Synthesis of a Universal Antigen to Detect Brucellosis


  • This work was made possible by a Natural Science and Engineering Research Council of Canada Discovery grant to D.R.B.


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Upgrading diagnostics: A universal antigen has been prepared for the detection of brucellosis caused by any Brucella species that express a smooth lipopolysaccharide. This nonasaccharide, which encompasses Brucella A- and M-antigenic determinants, is uniquely available only by chemical synthesis.