Carrier-free protein delivery: Protein self-assembly can be conducted in the extracellular matrix (ECM) where engineered protein components (ZR-ELP) form particles that become entrapped, bind a model protein (mCherry-ZE), and dissociate. Spontaneous diffusion–coacervation and high-affinity binding of proteins mediate in situ formation of the self-assembled particles that shrink and release the model protein in the ECM (see scheme).
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