Corrigendum: Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones

Authors

  • Daniel T. Cohen,

  • Dr. Chad C. Eichman,

  • Eric M. Phillips,

  • Emily R. Zarefsky,

  • Prof. Karl A. Scheidt

Errata

This article corrects:

  1. Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones Volume 51, Issue 29, 7309–7313, Article first published online: 14 June 2012

Table 1 of this Communication contains wrong data for the ee values of entries 1–7. The corrected entries are shown here.

Table 1. Reaction optimization.[a] inline image

Entry

Variation of the standard conditions

P:SM[b]

d.r.[c]

ee [%][d]

  1. [a] See the Supporting Information for details. [b] Ratio of product (P) to starting material (SM) determined by 1H NMR spectroscopy (500 MHz). Number in parentheses is the isolated yield of both diastereomers (on a 0.4 mmol scale). [c] Ratio determined by 1H NMR spectroscopy (500 MHz) prior to purification. [d] Enantiomeric excess of the major diastereomer determined by HPLC. [e] Starting material recovered. [f] Yield of major diastereomer only. … n.d. = not determined.

1

A, X=OEt

2:3

4:1

n.d.

2

B, X=OEt

1.2:1

5:1

n.d.

3

C, X=OEt

1:20

[e]

4

D, X=OEt

1:3

4:1

n.d.

5

E, X=OEt

>20:1 (31)[f]

7:1

90

6

F, X=OEt

>20:1 (72)

5:1

99

7

F, X=NBn2

>20:1

1:1

n.d.

original image

Ancillary