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Keywords:

  • GPCR;
  • homology modeling;
  • olfactory receptor;
  • protein structures;
  • receptors
Thumbnail image of graphical abstract

Receptor–ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant–receptor recognition.