These authors contributed equally to this work.
Opsin, a Structural Model for Olfactory Receptors?†
Article first published online: 26 AUG 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 42, pages 11021–11024, October 11, 2013
How to Cite
Park, J. H., Morizumi, T., Li, Y., Hong, J. E., Pai, E. F., Hofmann, K. P., Choe, H.-W. and Ernst, O. P. (2013), Opsin, a Structural Model for Olfactory Receptors?. Angew. Chem. Int. Ed., 52: 11021–11024. doi: 10.1002/anie.201302374
We thank the staff at the beamline BL14.2 at BESSY-MX/Helmholtz Zentrum Berlin for materials and energy, Yong Ju Kim for help with data collection, and Patrick Scheerer for help in early stages of the project. J.H.P. thanks Prof. Kui-Jea Lee for support. This work was supported in part by research funds of Chonbuk National University and a grant from Yu-dang, Ji Sung Yang Memorial Fund in 2011/2012 (to J.H.P.), by a grant from the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0002738 to H.-W.C.), a European Research Council Advanced Grant (to K.P.H.), a grant from the Deutsche Forschungsgemeinschaft (SFB449 to O.P.E.), the Canada Research Chair program (to E.F.P.), and the Canada Excellence Research Chair program (to O.P.E.). O.P.E. holds the Anne and Max Tanenbaum Chair in Neuroscience at the University of Toronto. Coordinates and structure factors of the opsin structure have been deposited in the Protein Data Bank with accession code 4J4Q.
- Issue published online: 10 OCT 2013
- Article first published online: 26 AUG 2013
- Manuscript Revised: 30 JUL 2013
- Manuscript Received: 20 MAR 2013
- Chonbuk National University
- Ministry of Education, Science and Technology. Grant Number: 2010-0002738
- European Research Council Advanced Grant
- Deutsche Forschungsgemeinschaft
- Canada Research Chair program
- Canada Excellence Research Chair program
- homology modeling;
- olfactory receptor;
- protein structures;
Receptor–ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant–receptor recognition.