Back Cover: A Chemical Probe for Lysine Malonylation (Angew. Chem. Int. Ed. 18/2013)



original image

Lysine malonylation is a newly identified posttranslational protein modification, whose cellular functions remain largely unknown. In their Communication on page 4883 ff., Y. M. E. Fung, X. D. Li, and co-workers develop the first chemical reporter, MalAM-yne, to detect malonylation of proteins in living cells. The subsequent bioorthogonal conjugation enables the visualization of the dynamics of malonylation and rapid profiling of malonylated proteins.