These authors contributed equally to this work.
Back Cover: A Chemical Probe for Lysine Malonylation (Angew. Chem. Int. Ed. 18/2013)
Article first published online: 8 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 18, page 4956, April 26, 2013
How to Cite
Bao, X., Zhao, Q., Yang, T., Fung, Y. M. E. and Li, X. D. (2013), Back Cover: A Chemical Probe for Lysine Malonylation (Angew. Chem. Int. Ed. 18/2013). Angew. Chem. Int. Ed., 52: 4956. doi: 10.1002/anie.201302391
- Issue published online: 21 APR 2013
- Article first published online: 8 APR 2013
- click chemistry;
- lysine malonylation;
- metabolic labeling;
- posttranslational modifications;
- protein modifications
Lysine malonylation is a newly identified posttranslational protein modification, whose cellular functions remain largely unknown. In their Communication on page 4883 ff., Y. M. E. Fung, X. D. Li, and co-workers develop the first chemical reporter, MalAM-yne, to detect malonylation of proteins in living cells. The subsequent bioorthogonal conjugation enables the visualization of the dynamics of malonylation and rapid profiling of malonylated proteins.