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Supramolecular Iron Porphyrin/Cyclodextrin Dimer Complex that Mimics the Functions of Hemoglobin and Methemoglobin

Authors

  • Dr. Kenji Watanabe,

    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
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  • Dr. Hiroaki Kitagishi,

    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
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  • Prof. Dr. Koji Kano

    Corresponding author
    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
    • Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)

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  • This work was supported by Grants-in-Aid on “Creating Research Center for Advanced Molecular Biochemistry”, Strategic Development of Research Infrastructure for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology. We are grateful to Prof. Dr. Akira Kawaguchi for helpful discussions. The animal experiments were performed in accordance with the Guidelines for Animal Experiments of Doshisha University.

Abstract

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A real life saver: A supramolecule (met-hemoCD3, see scheme) was prepared by including a water-soluble porphinato iron(III) in a capsule of a cyclodextrin dimer (Py3OCD), which was synthesized in only two steps. The structure of met-hemoCD3 was determined by X-ray crystal analysis (see picture). Ferrous hemoCD3 showed functions similar to those of hemoglobin/myoglobin and also functioned as an antidote for cyanide poisoning.

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