We thank Dr. Peter Mayer (LMU Munich) for the determination of the X-ray structure and Dr. Martin Sumser (LMU Munich) for many helpful discussions. This work was supported by the European Science Foundation (ERC grant no. 268795 to D.T.) and the Fonds der Chemischen Industrie (PhD fellowship to M.S.).
Optical Control of TRPV1 Channels†
Article first published online: 19 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 37, pages 9845–9848, September 9, 2013
How to Cite
Stein, M., Breit, A., Fehrentz, T., Gudermann, T. and Trauner, D. (2013), Optical Control of TRPV1 Channels . Angew. Chem. Int. Ed., 52: 9845–9848. doi: 10.1002/anie.201302530
- Issue published online: 3 SEP 2013
- Article first published online: 19 JUL 2013
- Manuscript Revised: 9 MAY 2013
- Manuscript Received: 26 MAR 2013
- European Science Foundation. Grant Number: 268795
- Fonds der Chemischen Industrie
Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.