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Keywords:

  • bactericidal;
  • N. meningitidis;
  • oligosaccharides;
  • total synthesis;
  • vaccine
Thumbnail image of graphical abstract

Sweetening the deal: N. meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide–protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.