A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery

Authors

  • Dr. Zilong Zhao,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Hongmin Meng,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Nannan Wang,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Michael J. Donovan,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Ting Fu,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Dr. Mingxu You,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Prof. Zhuo Chen,

    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Prof. Xiaobing Zhang,

    Corresponding author
    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
    • Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • Prof. Weihong Tan

    Corresponding author
    1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
    • Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
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  • This work is supported by the National Key Scientific Program of China (2011CB911000), the Foundation for Innovative Research Groups of NSFC (Grant 21221003), and China National Instrumentation Program 2011YQ03012412.

Abstract

original image

This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).

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