Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation


  • This study was supported in part by grants from the US National Institutes of Health (NIBIB R01 EB008111, NCI R01 CA171651 and SIG 1S10RR031625-01) and the National Science Foundation (CCF 0963742). Time-resolved fluorescence and absorption experiments were performed in Ultrafast Laser Facility of the Photosynthetic Antenna Research Center (PARC), an Energy Frontier Research Center funded by the U.S. Department of Energy (DE-SC 0001035). We thank Dr. Mikhail Berezin, Dr. Monica Shokeen, Dr. Yuan-Chuan Tai, and Sergey Komarov for helpful discussions.


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Let me get my nanoruler: Activatable probes based on radionuclide and quantum dots (QDs) were constructed using DNA as a linker. Cerenkov radiation from 64Cu was used to excite the QDs in a distance-dependent manner. The luminescence was lowest nearest to the QD and increased with distance.