A Highly Step-Economical Synthesis of Dictyostatin


  • This work was supported by a grant form the National Institute of General Medical Sciences (GM058133).


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Less is more: An efficient synthesis of the anti-mitotic macrolide dictyostatin proceeds with a longest linear sequence of 14 steps, and allows the rapid production of multi-gram quantities of each of the three fragments from which the natural product is assembled in just four or five steps. The key step is a scalable one-step synthesis of the C(12)–C(14) and C(20)–C(22) stereotriads.