This work was supported by a grant form the National Institute of General Medical Sciences (GM058133).
A Highly Step-Economical Synthesis of Dictyostatin†
Article first published online: 10 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 26, pages 6757–6761, June 24, 2013
How to Cite
Ho, S., Bucher, C. and Leighton, J. L. (2013), A Highly Step-Economical Synthesis of Dictyostatin . Angew. Chem. Int. Ed., 52: 6757–6761. doi: 10.1002/anie.201302565
- Issue published online: 20 JUN 2013
- Article first published online: 10 MAY 2013
- Manuscript Received: 27 MAR 2013
- National Institute of General Medical Sciences
- total synthesis
Less is more: An efficient synthesis of the anti-mitotic macrolide dictyostatin proceeds with a longest linear sequence of 14 steps, and allows the rapid production of multi-gram quantities of each of the three fragments from which the natural product is assembled in just four or five steps. The key step is a scalable one-step synthesis of the C(12)–C(14) and C(20)–C(22) stereotriads.