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Keywords:

  • dictyostatin;
  • scalability;
  • step-economy;
  • stereotriad;
  • total synthesis
Thumbnail image of graphical abstract

Less is more: An efficient synthesis of the anti-mitotic macrolide dictyostatin proceeds with a longest linear sequence of 14 steps, and allows the rapid production of multi-gram quantities of each of the three fragments from which the natural product is assembled in just four or five steps. The key step is a scalable one-step synthesis of the C(12)–C(14) and C(20)–C(22) stereotriads.