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Keywords:

  • biophysics;
  • DNA nanotechnology;
  • DNA structures;
  • force spectroscopy;
  • single-molecule experiments
Thumbnail image of graphical abstract

Bridging the gap: Rigid DNA linkers (blue, see picture) between microspheres (green) for high-resolution single-molecule mechanical experiments were constructed using DNA origami. The resulting DNA helical bundles greatly reduce the noise generated in studies of conformation changes using optical tweezers and were applied to study small DNA secondary structures.