We are grateful to the ETH Zürich and the Swiss National Science Foundation for financial support.
Iridium-Catalyzed Enantioselective Allylic Alkynylation†
Article first published online: 27 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 29, pages 7532–7535, July 15, 2013
How to Cite
Hamilton, J. Y., Sarlah, D. and Carreira, E. M. (2013), Iridium-Catalyzed Enantioselective Allylic Alkynylation . Angew. Chem. Int. Ed., 52: 7532–7535. doi: 10.1002/anie.201302731
- Issue published online: 11 JUL 2013
- Article first published online: 27 MAY 2013
- Manuscript Received: 3 APR 2013
- ETH Zürich
- Swiss National Science Foundation
- allylic substitution;
No leaving group needed: With an Ir(P,olefin) complex as catalyst, the direct enantioselective allylic alkynylation of secondary allylic alcohols with potassium alkynyltrifluoroborates as alkynylating reagents has been achieved. High levels of enantioselectivity and high yields were achieved with this operationally easy and robust protocol, the use of which was demonstrated in the synthesis of GPR40 receptor agonist AMG 837. cod=1,5-cyclooctadiene.