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Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete

Authors

  • Dr. Kyoung Hwa Jang,

    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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  • Dr. Sang-Jip Nam,

    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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  • Dr. Jeffrey B. Locke,

    1. Trius Therapeutics, 6310 Nancy Ridge Dr., Ste. 105, San Diego, CA 92121 (USA)
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  • Christopher A. Kauffman,

    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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  • Deanna S. Beatty,

    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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  • Lauren A. Paul,

    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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  • Prof. Dr. William Fenical

    Corresponding author
    1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
    • Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA)
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Errata

This article is corrected by:

  1. Errata: Corrigendum: Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete Volume 53, Issue 3, 621, Article first published online: 8 January 2014

  • This work was supported by the NIH (NIGMS) under grant 1RO1 GM084350, and in part by the Transformational Medical Technologies program contract HDTRA1-10-C-004 from the Department of Defense Chemical and Biological Defense Program through the Defense Threat Reduction Agency (DTRA). We thank Dr. Arnold Rheingold and Dr. Curtiss Moore (UCSD) for performing X-ray diffraction analysis.

Abstract

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Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

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