We thank Harshavardhan Reddy, Bharath Raj, and Bharath Srikanth for valuable discussions. This work was presented in BIOMOD 2012 at the Wyss Institute, Boston (USA). This work was funded by NCBS. Y.K. thanks Wellcome Trust-DBT India Alliance for a Senior Research fellowship. D.B. thanks CSRI, GoI for a research fellowship.
Controlled Release of Encapsulated Cargo from a DNA Icosahedron using a Chemical Trigger†
Article first published online: 28 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 27, pages 6854–6857, July 1, 2013
How to Cite
Banerjee, A., Bhatia, D., Saminathan, A., Chakraborty, S., Kar, S. and Krishnan, Y. (2013), Controlled Release of Encapsulated Cargo from a DNA Icosahedron using a Chemical Trigger. Angew. Chem. Int. Ed., 52: 6854–6857. doi: 10.1002/anie.201302759
- Issue published online: 21 JUN 2013
- Article first published online: 28 MAY 2013
- Manuscript Received: 3 APR 2013
- Wellcome Trust
- cargo release;
- DNA icosahedron;
- drug delivery;
DNA Trojan horse: A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo.