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Keywords:

  • aptamers;
  • cargo release;
  • DNA icosahedron;
  • drug delivery;
  • encapsulation
Thumbnail image of graphical abstract

DNA Trojan horse: A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo.