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Salicylic Acid and Analogues as diaCEST MRI Contrast Agents with Highly Shifted Exchangeable Proton Frequencies

Authors

  • Xing Yang,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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    • These authors contributed equally to this work.

  • Xiaolei Song,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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    • These authors contributed equally to this work.

  • Yuguo Li,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Guanshu Liu,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway Ave., Baltimore, MD 21287 (USA)
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  • Prof. Sangeeta Ray Banerjee,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Martin G. Pomper,

    Corresponding author
    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    • The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Michael T. McMahon

    Corresponding author
    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway Ave., Baltimore, MD 21287 (USA)
    • The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Financial support from the NIH (R01EB015031, R01EB012590, R01134675, and U54CA151838) is acknowledged. diaCEST=diamagnetic chemical exchange saturation transfer, MRI=magnetic resonance imaging.

Abstract

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More than water: Chemical exchange saturation transfer (CEST) contrast agents have used water bound to lanthanides as a source of highly shifted exchangeable proton frequencies. Compounds with the 2-hydroxybenzoic acid scaffold were investigated as a source of highly shifted protons for CEST MRI contrasting.

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