Direct C[BOND]H Amination of Arenes with Alkyl Azides under Rhodium Catalysis


  • This research was supported financially by the Institute of Basic Science (IBS).


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New horizons in the utility of azides: The rhodium-catalyzed intermolecular direct C[BOND]H amination of arenes with alkyl azides provides a convenient route to N-alkyl anilines (see scheme; DG=directing group). Alkyl azides with a wide range of functional groups reacted readily with various substrates, including benzamides, aromatic ketones, and flavones.