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Keywords:

  • amines;
  • asymmetric catalysis;
  • enantioselectivity;
  • heterocycles;
  • palladium
Thumbnail image of graphical abstract

Sly as Nicox: A palladium-catalyzed addition of arylboronic acids to ketimines has been developed to efficiently provide products in up to 99 % yield and 96 % ee. The reactions could be run under aerobic conditions and with unpurified trifluoroethanol (TFE). A pyrrolidine compound bearing a chiral α-tertiary amine was synthesized in several steps without loss of enantioselectivity. TFA=trifluoroacetate.