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Polymer Nanomicelles for Efficient Mucus Delivery and Antigen-Specific High Mucosal Immunity

Authors

  • Young-Woock Noh,

    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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    • These authors contributed equally to this work.

  • Ji Hyun Hong,

    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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    • These authors contributed equally to this work.

  • Sang-Mu Shim,

    1. Virus Infectious Disease Research and Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Republic of Korea)
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    • These authors contributed equally to this work.

  • Hye Sun Park,

    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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  • Hee Ho Bae,

    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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  • Eun Kyoung Ryu,

    1. Division of Magnetic Resonance Research, Korea Basic Science Institute, Ochang, Chungbuk (Republic of Korea)
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  • Jung Hwan Hwang,

    1. Virus Infectious Disease Research and Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Republic of Korea)
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  • Dr. Chul-Ho Lee,

    1. Virus Infectious Disease Research and Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Republic of Korea)
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  • Seong Hun Cho,

    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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  • Dr. Moon-Hee Sung,

    1. Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul (Republic of Korea)
    2. BioLeaders Corporation, Daejeon (Republic of Korea)
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  • Dr. Haryoung Poo,

    Corresponding author
    1. Virus Infectious Disease Research and Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Republic of Korea)
    • Virus Infectious Disease Research and Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Republic of Korea)
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  • Prof. Dr. Yong Taik Lim

    Corresponding author
    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
    • Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon (Republic of Korea)
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  • The authors acknowledge the financial support from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (grant numbers 2010-0026793 and 2012M3A9C6050070), the Korea Health Technology R&D Project, Ministry of Health & Welfare (grant number A111918), the National Agenda Project grant from the Korea Research Council of Fundamental Science and Technology, and the Korean Ministry of Knowledge Economy (grant number TGM0231213).

Abstract

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Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).

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