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Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue


  • This work was supported by the National Science Foundation (CAREER: DMR-0847253 to H.K., CBET-10-33906 to S.B. and H.K., CBET-08-52658-ARRA to S.B., Emerging Behavior of Integrated Cellular Systems: CBET-0939551 to H.K.), and the University of Illinois’ Center for Advanced Study (H.K.)


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Hydrogel meets silicone: The chemical functionalization of a polydimethylsiloxane (PDMS) surface with polysaccharide “glue” induces a strong, permanent adhesion between the hydrogel and PDMS. This hydrogel-coated silicone substrate was useful for controlling cellular organization under mechanical stretching (see picture) and also in fabricating microfluidic devices filled with the gel.