Eastman Chemical Company and the Rubicon Program of the NWO are acknowledged for financial support to T.B. and R.G.-D., respectively.
Remotely Controlled Iridium-Catalyzed Asymmetric Hydrogenation of Terminal 1,1-Diaryl Alkenes†
Article first published online: 24 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 34, pages 8795–8797, August 19, 2013
How to Cite
Besset, T., Gramage-Doria, R. and Reek, J. N. H. (2013), Remotely Controlled Iridium-Catalyzed Asymmetric Hydrogenation of Terminal 1,1-Diaryl Alkenes. Angew. Chem. Int. Ed., 52: 8795–8797. doi: 10.1002/anie.201302942
- Issue published online: 14 AUG 2013
- Article first published online: 24 JUL 2013
- Manuscript Received: 9 APR 2013
- asymmetric hydrogenation;
- directing groups;
- iridium catalysts;
- terminal alkenes
Working together: The presence of a remote directing group on terminal 1,1-diaryl and 1,1-dialkyl alkenes led to high and unprecedented enantioselectivity in iridium-catalyzed asymmetric hydrogenation (see scheme). This strategy offers efficient synthetic pathways towards valuable enantiomerically enriched 1,1-diaryl and 1,1-dialkyl alkanes. Moreover, the directing group can be further functionalized.