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Keywords:

  • asymmetric hydrogenation;
  • directing groups;
  • enantioselectivity;
  • iridium catalysts;
  • terminal alkenes
Thumbnail image of graphical abstract

Working together: The presence of a remote directing group on terminal 1,1-diaryl and 1,1-dialkyl alkenes led to high and unprecedented enantioselectivity in iridium-catalyzed asymmetric hydrogenation (see scheme). This strategy offers efficient synthetic pathways towards valuable enantiomerically enriched 1,1-diaryl and 1,1-dialkyl alkanes. Moreover, the directing group can be further functionalized.