A Two-Channel Ratiometric Electrochemical Biosensor for In Vivo Monitoring of Copper Ions in a Rat Brain Using Gold Truncated Octahedral Microcages


  • This work was financially supported by the NSFC (grant numbers 20975075, 21175098, 21101117, and 21175044) and the Fundamental Research Funds for the Central Universities.


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Brain chemistry: A biosensor has been developed for in vivo determination of copper ions in a rat brain by using gold truncated octahedral microcages. The significant analytical performance of the present biosensor, as well as the properties of a carbon fiber microelectrode have provided a direct and reliable approach for monitoring cerebral metal ions (W.E.=working electrode; see picture).