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Keywords:

  • asymmetric catalysis;
  • catalyst design;
  • hydrogenation;
  • iridium;
  • synthetic methods
Thumbnail image of graphical abstract

High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency.