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Catalytic Asymmetric Hydrogenation of δ-Ketoesters: Highly Efficient Approach to Chiral 1,5-Diols


  • We thank the National Natural Science Foundation of China, the National Basic Research Program of China (2010CB833300), and the “111” project of the Ministry of Education of China (Grant No. B06005) for financial support.


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High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency.

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